Acute Kidney Injury in Patients on Concomitant Vancomycin and Piperacillin/Tazobactam: Are Extended Infusions to Blame?

A Case of Acute Kidney Injury with Vancomycin and Piperacillin/Tazobactam

Acute kidney injury can result from a multitude of factors, including drug-induced causes. Medications like vancomycin and piperacillin/tazobactam have shown to be correlated with deterioration of the kidneys when used in excess or concomitantly with other potential offending agents [1,2]. While these agents have been both been associated with potential nephrotoxcity there is limited data on th...

Late-Occurring Vancomycin-Associated Acute Kidney Injury in Children Receiving Prolonged Therapy.

BACKGROUND Acute kidney injury (AKI) in patients receiving vancomycin has been associated with trough concentrations ≥15 mg/L and longer therapy duration. The objective of this study was to determine the incidence and factors associated with late AKI in children receiving ≥8 days of vancomycin therapy. METHODS Children aged 30 days to 17 years who were admitted to our institution and received...

Impact of Obesity on Acute Kidney Injury Incidence Among Patients Treated with Piperacillin–Tazobactam and Vancomycin

Comparison of Rates of Acute Kidney Injury with Vancomycin/Piperacillin-Tazobactam vs. Vancomycin/Meropenem Combination Therapy

The Nephrotoxicity of Vancomycin

Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to what extent vancomycin is directly responsible, as numerous potential risk factors for acute kidney injury frequently coexist. Herein, we critically examine available data in adult patients pertinent to this question. We review the pharmacokinetics/pharmacodynamics of vancomycin metabolism. Efficacy and sa...